The mild pulmonary (lung) form of histoplasmosis will generally resolve within about a month without treatment.
Prescription antifungal medications are needed to treat severe cases of acute histoplasmosis and all cases of chronic or disseminated disease. Itraconazole is one commonly used antifungal medication. Treatment may continue for three to 12 months, depending on the severity of the disease and the immune status of the person. Past infection can provide partial protection against severe infectious diseases if a person becomes reinfected later in life.
For health care providers: the most up-to-date treatment and practice guidelines from the Infectious Diseases Society of America can be found at the Infectious Diseases Society of America website (www.idsociety.org).